ITT4894
ITT4894
- Catalog: ITT4894
- Gene/Protein: VTI1A
- Product Description: Immunotag™ v-SNARE Vti1a Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | v-SNARE Vti1a |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from v-SNARE Vti1a, at AA range: 1-80 |
| Specificity | v-SNARE Vti1a Polyclonal Antibody detects endogenous levels of v-SNARE Vti1a protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | VTI1A |
| Accession No. | Q96AJ9 O89116 Q9JI51 |
| Alternate Names | VTI1A; Vesicle transport through interaction with t-SNAREs homolog 1A; Vesicle transport v-SNARE protein Vti1-like 2; Vti1-rp2 |
| Description | vesicle transport through interaction with t-SNAREs 1A(VTI1A) Homo sapiens The protein encoded by this gene is a member of the family of soluble N-ethylmaleimide-sensitive fusion protein-attachment protein receptors (SNAREs) that function in intracellular trafficking. This family member is involved in vesicular transport between endosomes and the trans-Golgi network. It is a vesicle-associated SNARE (v-SNARE) that interacts with target membrane SNAREs (t-SNAREs). Polymorphisms in this gene have been associated with binocular function, and also with susceptibility to colorectal and lung cancers. A recurrent rearrangement has been found between this gene and the transcription factor 7-like 2 (TCF7L2) gene in colorectal cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015], |
| Cell Pathway/ Category | SNARE interactions in vesicular transport, |
| Protein Expression | Lung, |
| Subcellular Localization | Golgi membrane,endosome,autophagosome,endoplasmic reticulum membrane,Golgi apparatus,cytosol,synaptic vesicle,ER to Golgi transport vesicle membrane,integral component of membrane,clathrin-coated vesicle,SNA |
| Protein Function | function:V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. May be concerned with increased secretion of cytokines associated with cellular senescence.,similarity:Belongs to the VTI1 family., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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