ITT4949
ITT4949
- Catalog: ITT4949
- Gene/Protein: SLC39A4
- Product Description: Immunotag™ ZIP4 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | ZIP4 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human |
| Host Species | Rabbit |
| Immunogen | The antiserum was produced against synthesized peptide derived from human SLC39A4. AA range:431-480 |
| Specificity | ZIP4 Polyclonal Antibody detects endogenous levels of ZIP4 protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | SLC39A4 |
| Accession No. | Q6P5W5 Q78IQ7 |
| Alternate Names | SLC39A4; ZIP4; Zinc transporter ZIP4; Solute carrier family 39 member 4; Zrt- and Irt-like protein 4; ZIP-4 |
| Description | solute carrier family 39 member 4(SLC39A4) Homo sapiens This gene encodes a member of the zinc/iron-regulated transporter-like protein (ZIP) family. The encoded protein localizes to cell membranes and is required for zinc uptake in the intestine. Mutations in this gene result in acrodermatitis enteropathica. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2013], |
| Protein Expression | Lung,Ovary, |
| Subcellular Localization | plasma membrane,integral component of plasma membrane,integral component of membrane,cytoplasmic, membrane-bounded vesicle,apical plasma membrane,cytoplasmic vesicle,recycling endosome membrane,extracellular exosome, |
| Protein Function | disease:Defects in SLC39A4 are the cause of acrodermatitis enteropathica zinc-deficiency type (AEZ) [MIM:201100]. AEZ is a rare autosomal recessive disease caused by the inability to absorb sufficient zinc. The clinicals features are growth retardation, immune system dysfunction, alopecia, severe dermatitis, diarrhea and occasionally mental disorders. All these manifestations are reversible with zinc supplementation. Without zinc therapy this disease is fatal.,function:Plays an important role in cellular zinc homeostasis as a zinc transporter. Regulated in response to zinc availability.,similarity:Belongs to the ZIP transporter (TC 2.A.5) family.,subcellular location:Colocalized with TFRC in the recycling endosomes. Cycles between endosomal compartments and the plasma membrane in response to zinc availability.,tissue specificity:Highly expressed in kidney, small intestine, stomach, colon, jejunum and duodenum., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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