ITT5123
ITT5123
- Catalog: ITT5123
- Gene/Protein: CMA1
- Product Description: Immunotag™ Chymase Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | Chymase |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from the Internal region of human Chymase. |
| Specificity | Chymase Polyclonal Antibody detects endogenous levels of Chymase protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | CMA1 |
| Accession No. | P23946 P21844 |
| Alternate Names | CMA1; CYH; CYM; Chymase; Alpha-chymase; Mast cell protease I |
| Description | chymase 1(CMA1) Homo sapiens This gene encodes a chymotryptic serine proteinase that belongs to the peptidase family S1. It is expressed in mast cells and is thought to function in the degradation of the extracellular matrix, the regulation of submucosal gland secretion, and the generation of vasoactive peptides. In the heart and blood vessels, this protein, rather than angiotensin converting enzyme, is largely responsible for converting angiotensin I to the vasoactive peptide angiotensin II. Alternative splicing results in multiple variants. [provided by RefSeq, Apr 2015], |
| Cell Pathway/ Category | Renin-angiotensin system, |
| Protein Expression | Heart,Liver,PCR rescued clones,Placenta, |
| Subcellular Localization | extracellular region,cytoplasm,extracellular matrix,intracellular membrane-bounded organelle, |
| Protein Function | catalytic activity:Preferential cleavage: Phe-|-Xaa > Tyr-|-Xaa > Trp-|-Xaa > Leu-|-Xaa.,function:Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion.,similarity:Belongs to the peptidase S1 family.,similarity:Belongs to the peptidase S1 family. Granzyme subfamily.,similarity:Contains 1 peptidase S1 domain.,subcellular location:Mast cell granules.,tissue specificity:Mast cells in lung, heart, skin and placenta., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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