ITT5130
ITT5130
- Catalog: ITT5130
- Gene/Protein: SELL
- Product Description: Immunotag™ L-Selectin Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | L-Selectin |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,IHC-p,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. IHC-p: 1:100-300 ELISA: 1/20000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from L-Selectin, at AA range: 60-140 |
| Specificity | L-Selectin Polyclonal Antibody detects endogenous levels of L-Selectin protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | SELL |
| Accession No. | P14151 P18337 P30836 |
| Alternate Names | SELL; LNHR; LYAM1; L-selectin; CD62 antigen-like family member L; Leukocyte adhesion molecule 1; LAM-1; Leukocyte surface antigen Leu-8; Leukocyte-endothelial cell adhesion molecule 1; LECAM1; Lymph node homing receptor; TQ1; gp90-MEL; CD62L |
| Description | selectin L(SELL) Homo sapiens This gene encodes a cell surface adhesion molecule that belongs to a family of adhesion/homing receptors. The encoded protein contains a C-type lectin-like domain, a calcium-binding epidermal growth factor-like domain, and two short complement-like repeats. The gene product is required for binding and subsequent rolling of leucocytes on endothelial cells, facilitating their migration into secondary lymphoid organs and inflammation sites. Single-nucleotide polymorphisms in this gene have been associated with various diseases including immunoglobulin A nephropathy. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2009], |
| Cell Pathway/ Category | Cell adhesion molecules (CAMs), |
| Protein Expression | Hematopoietic,Lung,Lymphocyte,Plasma,Tonsil, |
| Subcellular Localization | plasma membrane,integral component of plasma membrane,external side of plasma membrane,membrane,integral component of membrane, |
| Protein Function | function:Cell surface adhesion protein. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia.,online information:L-selectin,similarity:Belongs to the selectin/LECAM family.,similarity:Contains 1 C-type lectin domain.,similarity:Contains 1 EGF-like domain.,similarity:Contains 2 Sushi (CCP/SCR) domains.,subunit:Interaction with PSGL1/SELPLG is required for promoting recruitment and rolling of leukocytes. This interaction is dependent on the sialyl Lewis X glycan and tyrosine sulfation modifications of PSGL1. Sulfation on Y-51 of PSGL1 is important for L-selectin binding.,tissue specificity:Expressed in B cell lines and T lymphocytes., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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