ITT5212
ITT5212
- Catalog: ITT5212
- Gene/Protein: FSCN1
- Product Description: Immunotag™ Fascin 1 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | Fascin 1 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,IHC-p,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. IHC-p: 1:100-300 ELISA: 1/20000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from Fascin 1, at AA range: 261-310 |
| Specificity | Fascin 1 Polyclonal Antibody detects endogenous levels of Fascin 1 protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | FSCN1 |
| Accession No. | Q16658 Q61553 P85845 |
| Alternate Names | FSCN1; FAN1; HSN; SNL; Fascin; 55 kDa actin-bundling protein; Singed-like protein; p55 |
| Description | fascin actin-bundling protein 1(FSCN1) Homo sapiens This gene encodes a member of the fascin family of actin-binding proteins. Fascin proteins organize F-actin into parallel bundles, and are required for the formation of actin-based cellular protrusions. The encoded protein plays a critical role in cell migration, motility, adhesion and cellular interactions. Expression of this gene is known to be regulated by several microRNAs, and overexpression of this gene may play a role in the metastasis of multiple types of cancer by increasing cell motility. Expression of this gene is also a marker for Reed-Sternberg cells in Hodgkin's lymphoma. A pseudogene of this gene is located on the long arm of chromosome 15. [provided by RefSeq, Sep 2011], |
| Protein Expression | Brain,Cajal-Retzius cell,Eye,Fetal brain cortex,Lung,Muscle,Teratocarcinoma |
| Subcellular Localization | stress fiber,ruffle,podosome,cytoplasm,cytosol,cytoskeleton,microvillus,cell-cell junction,cell-cell adherens junction,actin cytoskeleton,lamellipodium,filopodium,growth cone,cell projection membran |
| Protein Function | disease:Marks and mediates breast cancer metastasis to the lungs. FSCN1 is not functionally validated but achieves the highest statistical significance (P less than 0.000001). Those subjects expressing the lung metastasis signature have a significantly poorer lung metastasis-free survival, but not bone metastasis-free survival, compared to subjects without the signature.,function:Organizes filamentous actin into bundles with a minimum of 4.1:1 actin/fascin ratio. Probably involved in the assembly of actin filament bundles present in microspikes, membrane ruffles, and stress fibers.,PTM:Phosphorylation on Ser-39 inhibits the actin-binding ability of fascin.,similarity:Belongs to the fascin family.,subunit:Associates with beta-catenin.,tissue specificity:Ubiquitous., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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