ITT5220
ITT5220
- Catalog: ITT5220
- Gene/Protein: PDIA3
- Product Description: Immunotag™ ERp57 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | ERP57 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,IHC-p,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. IHC-p: 1:100-300 ELISA: 1/20000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from ERp57, at AA range: 111-160 |
| Specificity | ERp57 Polyclonal Antibody detects endogenous levels of ERp57 protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | PDIA3 |
| Accession No. | P30101 P27773 P11598 |
| Alternate Names | PDIA3; ERP57; ERP60; GRP58; Protein disulfide-isomerase A3; 58 kDa glucose-regulated protein; 58 kDa microsomal protein; p58; Disulfide isomerase ER-60;Endoplasmic reticulum resident protein 57; ER protein 57; ERp57; Endoplasmic reticulum resident protein 60; ER protein 60; ERp60 |
| Description | protein disulfide isomerase family A member 3(PDIA3) Homo sapiens This gene encodes a protein of the endoplasmic reticulum that interacts with lectin chaperones calreticulin and calnexin to modulate folding of newly synthesized glycoproteins. The protein was once thought to be a phospholipase; however, it has been demonstrated that the protein actually has protein disulfide isomerase activity. It is thought that complexes of lectins and this protein mediate protein folding by promoting formation of disulfide bonds in their glycoprotein substrates. [provided by RefSeq, Jul 2008], |
| Cell Pathway/ Category | Antigen processing and presentation, |
| Protein Expression | Brain,Cajal-Retzius cell,Colon carcinoma,Fetal brain cortex |
| Subcellular Localization | cell,nucleus,endoplasmic reticulum,endoplasmic reticulum lumen,focal adhesion,cell surface,melanosome,myelin sheath,extracellular exosome, |
| Protein Function | catalytic activity:Catalyzes the rearrangement of -S-S- bonds in proteins.,caution:Was originally thought to be a phosphatidylinositol-4,5-bisphosphate phosphodiesterase type I (phospholipase C-alpha).,mass spectrometry: PubMed:11840567,similarity:Belongs to the protein disulfide isomerase family.,similarity:Contains 2 thioredoxin domains.,subcellular location:Identified by mass spectrometry in melanosome fractions from stage I to stage IV.,subunit:Interacts with ERP27 and CANX., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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