ITT5240
ITT5240
- Catalog: ITT5240
- Gene/Protein: CD1E
- Product Description: Immunotag™ CD1E Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
|
| Target Protein | CD1E |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,IHC-p,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. IHC-p: 1:100-300 ELISA: 1/20000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human |
| Host Species | Rabbit |
| Immunogen | The antiserum was produced against synthesized peptide derived from the C-terminal region of human CD1E. AA range:321-370 |
| Specificity | CD1E Polyclonal Antibody detects endogenous levels of CD1E protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | CD1E |
| Accession No. | P15812 |
| Alternate Names | CD1E; T-cell surface glycoprotein CD1e, membrane-associated; hCD1e; R2G1; CD1e |
| Description | CD1e molecule(CD1E) Homo sapiens This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes within Golgi compartments, endosomes, and lysosomes, and is cleaved into a stable soluble form. The soluble form is required for the intracellular processing of some glycolipids into a form that can be presented by other CD1 family members. Many alternatively spliced transcript variants encoding different isoforms have been desc |
| Cell Pathway/ Category | Hematopoietic cell lineage, |
| Protein Expression | Thymus, |
| Subcellular Localization | Golgi membrane,early endosome,late endosome,plasma membrane,integral component of plasma membrane,integral component of membrane,lysosomal lumen, |
| Protein Function | function:Required for the presentation of glycolipid antigens on the cell surface.,PTM:Mono-ubiquitinated.,PTM:Proteolytically cleaved in endosomes to yield a soluble form.,similarity:Contains 1 Ig-like (immunoglobulin-like) domain.,subcellular location:Predominantly localized in the trans-Golgi network in immature dendritic cells, and as a cleaved, soluble protein in the lysosome lumen of mature dendritic cells.,subunit:Heterodimer with B2M (beta-2-microglobulin).,tissue specificity:Expressed on cortical thymocytes, dendritic cells, Langerhans cells, on certain T-cell leukemias, and in various other tissues., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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