ITT5249
ITT5249
- Catalog: ITT5249
- Gene/Protein: ICAM3
- Product Description: Immunotag™ CD50 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
|
| Target Protein | CD50 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,IHC-p,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. IHC-p: 1:100-300 ELISA: 1/20000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human |
| Host Species | Rabbit |
| Immunogen | The antiserum was produced against synthesized peptide derived from the Internal region of human ICAM3. AA range:271-320 |
| Specificity | CD50 Polyclonal Antibody detects endogenous levels of CD50 protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | ICAM3 |
| Accession No. | P32942 |
| Alternate Names | ICAM3; Intercellular adhesion molecule 3; ICAM-3; CDw50; ICAM-R; CD50 |
| Description | intercellular adhesion molecule 3(ICAM3) Homo sapiens The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein is constitutively and abundantly expressed by all leucocytes and may be the most important ligand for LFA-1 in the initiation of the immune response. It functions not only as an adhesion molecule, but also as a potent signalling molecule. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2016], |
| Cell Pathway/ Category | Cell adhesion molecules (CAMs), |
| Protein Expression | Blood,Liver,Lung,Plasma, |
| Subcellular Localization | plasma membrane,integral component of plasma membrane,membrane,integral component of membrane,extracellular exosome, |
| Protein Function | function:ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM3 is also a ligand for integrin alpha-D/beta-2.,online information:ICAM-3,PTM:N-glycosylated; glycans consist of a mixture of tri- and tetra-antennary complex-type chains and high-mannose chains.,PTM:Upon stimulation by a physiologic stimuli becomes rapidly and transiently phosphorylated on serine residues.,similarity:Belongs to the immunoglobulin superfamily. ICAM family.,similarity:Contains 5 Ig-like C2-type (immunoglobulin-like) domains., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
| English_US |
|
| Danish |
|
| Dutch |
|
| English_UK |
|
| French |
|
| German |
|
| Spanish |
|
| Norwegian |
|
| Portuguese |
|
| Finnish |
|
| Swedish |
|
| Polish |
|