ITT5254
ITT5254
- Catalog: ITT5254
- Gene/Protein: NT5E
- Product Description: Immunotag™ CD73 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | CD73 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,IHC-p,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. IHC-p: 1:100-300 ELISA: 1/20000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human |
| Host Species | Rabbit |
| Immunogen | The antiserum was produced against synthesized peptide derived from the Internal region of human NT5E. AA range:431-480 |
| Specificity | CD73 Polyclonal Antibody detects endogenous levels of CD73 protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | NT5E |
| Accession No. | P21589 Q61503 |
| Alternate Names | NT5E; NT5; NTE; 5'-nucleotidase; 5'-NT; Ecto-5'-nucleotidase; CD73 |
| Description | 5'-nucleotidase ecto(NT5E) Homo sapiens The protein encoded by this gene is a plasma membrane protein that catalyzes the conversion of extracellular nucleotides to membrane-permeable nucleosides. The encoded protein is used as a determinant of lymphocyte differentiation. Defects in this gene can lead to the calcification of joints and arteries. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2011], |
| Cell Pathway/ Category | Purine metabolism,Pyrimidine metabolism,Nicotinate and nicotinamide metabolism, |
| Protein Expression | Leukocyte,Liver,Placenta,Skin, |
| Subcellular Localization | cytoplasm,plasma membrane,cell surface,membrane,integral component of membrane,anchored component of membrane,extracellular exosome, |
| Protein Function | catalytic activity:A 5'-ribonucleotide + H(2)O = a ribonucleoside + phosphate.,cofactor:Zinc.,disease:There is a decrease in the activity of NT5 in B-cell chronic lymphocytic leukemia.,function:Hydrolyzes extracellular nucleotides into membrane permeable nucleosides.,similarity:Belongs to the 5'-nucleotidase family.,subunit:Homodimer; disulfide-linked., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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