ITT5261
ITT5261
- Catalog: ITT5261
- Gene/Protein: PVRL3
- Product Description: Immunotag™ Nectin 3 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
|
| Target Protein | Nectin 3 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Immunogen | The antiserum was produced against synthesized peptide derived from the Internal region of human PVRL3. AA range:311-360 |
| Specificity | Nectin 3 Polyclonal Antibody detects endogenous levels of Nectin 3 protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | PVRL3 |
| Accession No. | Q9NQS3 Q9JLB9 |
| Alternate Names | PVRL3; PRR3; Poliovirus receptor-related protein 3; CDw113; Nectin-3; CD113 |
| Description | nectin cell adhesion molecule 3(NECTIN3) Homo sapiens This gene encodes a member of the nectin family of proteins, which function as adhesion molecules at adherens junctions. This family member interacts with other nectin-like proteins and with afadin, a filamentous actin-binding protein involved in the regulation of directional motility, cell proliferation and survival. This gene plays a role in ocular development involving the ciliary body. Mutations in this gene are believed to result in congenital ocular defects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011], |
| Cell Pathway/ Category | Cell adhesion molecules (CAMs),Adherens_Junction, |
| Protein Expression | Brain,Cervix,Fetal kidney,Kidney,Placenta, |
| Subcellular Localization | plasma membrane,integral component of plasma membrane,cell-cell junction,cell-cell adherens junction,apical junction complex,cell-cell contact zone,postsynaptic membrane, |
| Protein Function | function:Plays a role in cell-cell adhesion through heterophilic trans-interactions with nectin-like proteins or nectins, such as trans-interaction with PVRL2/nectin-2 at Sertoli-spermatid junctions. Trans-interaction with PVR induces activation of CDC42 and RAC small G proteins through common signaling molecules such as SRC and RAP1. Also involved in the formation of cell-cell junctions, including adherens junctions and synapses. Induces endocytosis-mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and proliferation. Plays a role in the morphology of the ciliary body.,similarity:Belongs to the nectin family.,similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain.,similarity:Contains 2 Ig-like C2-type (immunoglobulin-like) domains.,subunit:Cis- and trans-homodimer. Can form trans-heterodimers with PVRL1/nectin-1, PVRL2/nectin-2, PVR, IGSF4B/Necl-1 and with IGSF4. Interacts with MLLT4/afadin. Binds with low affinity to TIGIT.,tissue specificity:Predominantly expressed in testis and placenta as well as in many cell lines, including epithelial cell lines., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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