ITT5320
ITT5320
- Catalog: ITT5320
- Gene/Protein: NUMB
- Product Description: Immunotag™ NUMB Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
|
| Target Protein | NUMB |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from the Internal region of human NUMB |
| Specificity | NUMB Polyclonal Antibody detects endogenous levels of NUMB protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | NUMB |
| Accession No. | P49757 Q9QZS3 Q2LC84 |
| Alternate Names | NUMB; Protein numb homolog; h-Numb; Protein S171 |
| Description | NUMB, endocytic adaptor protein(NUMB) Homo sapiens The protein encoded by this gene plays a role in the determination of cell fates during development. The encoded protein, whose degradation is induced in a proteasome-dependent manner by MDM2, is a membrane-bound protein that has been shown to associate with EPS15, LNX1, and NOTCH1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016], |
| Cell Pathway/ Category | Notch, |
| Protein Expression | B cells,Blood,Brain,Cervix carcinoma,Epithelium,Fetal brain,HeLa cells,Live |
| Subcellular Localization | nucleus,early endosome,plasma membrane,cell-cell adherens junction,focal adhesion,cytoplasmic, membrane-bounded vesicle,basolateral plasma membrane,extrinsic component of plasma membrane,clathrin-coated vesicle,apical part of cell, |
| Protein Function | function:Implicated in the control of cell fate decisions during development.,PTM:Isoform 1 and isoform 2 are ubiquitinated by LNX leading to their subsequent proteasomal degradation (By similarity). Ubiquitinated; mediated by SIAH1 and leading to its subsequent proteasomal degradation.,sequence caution:Intron retention.,similarity:Contains 1 PID domain.,subunit:Interacts with EPS15, LNX and NOTCH1. May interact with DUOXA1. Interacts with RALBP1 in a complex also containing EPN1 and TFAP2A during interphase and mitosis., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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