ITT5365
ITT5365
- Catalog: ITT5365
- Gene/Protein: ANGPT1
- Product Description: Immunotag™ Ang-1 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | Ang-1 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,IHC-p,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. IHC-p: 1/100-1/300. ELISA: 1/20000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Rat |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from Ang-1, at AA range: N-TERM |
| Specificity | Ang-1 Polyclonal Antibody detects endogenous levels of Ang-1 protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | ANGPT1 |
| Accession No. | Q15389 O08538 O35460 |
| Alternate Names | ANGPT1; KIAA0003; Angiopoietin-1; ANG-1 |
| Description | angiopoietin 1(ANGPT1) Homo sapiens This gene encodes a secreted glycoprotein that belongs to the angiopoietin family. Members of this family play important roles in vascular development and angiogenesis. All angiopoietins bind with similar affinity to an endothelial cell-specific tyrosine-protein kinase receptor. The protein encoded by this gene is a secreted glycoprotein that activates the receptor by inducing its tyrosine phosphorylation. It plays a critical role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme and inhibits endothelial permeability. The protein also contributes to blood vessel maturation and stability, and may be involved in early development of the heart. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Sep 2015], |
| Protein Expression | Bone marrow,Clones donated by Kazusa DNA Research Inst.,Fetal lung,Prostate,Small intestine |
| Subcellular Localization | extracellular region,extracellular space,intracellular,plasma membrane,microvillus,membrane raft,extracellular exosome, |
| Protein Function | function:Binds and activates TIE2 receptor by inducing its tyrosine phosphorylation. Implicated in endothelial developmental processes later and distinct from that of VEGF. Appears to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme. Mediates blood vessel maturation/stability. It may play an important role in the heart early development.,miscellaneous:It may have a potential therapeutic utility since it can be used for specifically targeting tumor vasculature or for promoting angiogenic processes in certain organs such as an ischemic heart.,online information:Angiopoietin entry,PTM:Glycosylated.,similarity:Contains 1 fibrinogen C-terminal domain., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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