ITT5457
ITT5457
- Catalog: ITT5457
- Gene/Protein: SNRPN
- Product Description: Immunotag™ SNRPN Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
|
| Target Protein | SNRPN |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from SNRPN, at AA range: 21-70 |
| Specificity | SNRPN Polyclonal Antibody detects endogenous levels of SNRPN protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | SNRPN |
| Accession No. | P63162 P63163 P63164 |
| Alternate Names | SNRPN; HCERN3; SMN; Small nuclear ribonucleoprotein-associated protein N; snRNP-N; Sm protein D; Sm-D; Sm protein N; Sm-N; SmN; Tissue-specific-splicing protein |
| Description | small nuclear ribonucleoprotein polypeptide N(SNRPN) Homo sapiens The protein encoded by this gene is one polypeptide of a small nuclear ribonucleoprotein complex and belongs to the snRNP SMB/SMN family. The protein plays a role in pre-mRNA processing, possibly tissue-specific alternative splicing events. Although individual snRNPs are believed to recognize specific nucleic acid sequences through RNA-RNA base pairing, the specific role of this family member is unknown. The protein arises from a bicistronic transcript that also encodes a protein identified as the SNRPN upstream reading frame (SNURF). Multiple transcription initiation sites have been identified and extensive alternative splicing occurs in the 5' untranslated region. Additional splice variants have been described but sequences for the complete transcripts have not been determined. The 5' UTR of this gene has been identified as an imprinting center. Alternative splici |
| Protein Expression | Brain,Cerebellum,Kidney,Uterus,Uterus endothel, |
| Subcellular Localization | spliceosomal complex,U5 snRNP,U1 snRNP,U2 snRNP,U4 snRNP,cytoplasm,viral nucleocapsid,small nuclear ribonucleoprotein complex,U4/U6 x U5 tri-snRNP complex,U2-type prespliceosome,catalytic step 2 spliceosome, |
| Protein Function | disease:Patients with the autoimmune disease systemic lupus erythematosus (SLE) have autoantibodies directed against some of the individual snRNP polypeptides. The most common autoantigen is called Sm. N bears Sm epitopes.,function:May be involved in tissue-specific alternative RNA processing events.,miscellaneous:Encoded on a bicistronic transcript that encode for two proteins, SNRPN and SNURF.,miscellaneous:Encoded on a bicistronic transcript that encode for two proteins, SNRPN and SNURF. In addition to the primary 1.6-kb bicistronic SNURF-SNRPN transcript, SNURF-only transcript is also detected.,similarity:Belongs to the snRNP SmB/SmN family.,similarity:Belongs to the SNURF family.,subunit:Interacts with TDRD3.,tissue specificity:Expressed in brain and lymphoblasts.,tissue specificity:Expressed in heart, skeletal muscle and lymphoblasts (at protein level). Expressed in brain, pancreas, heart, liver, lung, kidney and skeletal muscle., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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