ITT5536
ITT5536
- Catalog: ITT5536
- Gene/Protein: OAS2
- Product Description: Immunotag™ OAS2 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | OAS2 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,IHC-p,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. IHC-p: 1:100-1:300. ELISA: 1/20000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from 2'-5'-oligoadenylate synthase 2 at AA range: 61-110 |
| Specificity | OAS2 Polyclonal Antibody detects endogenous levels of OAS2 protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | OAS2 |
| Accession No. | P29728 E9Q9A9 Q5MYU0 |
| Alternate Names | OAS2; 2'-5'-oligoadenylate synthase 2; (2-5')oligo(A) synthase 2; 2-5A synthase 2; p69 OAS / p71 OAS; p69OAS / p71OAS |
| Description | 2'-5'-oligoadenylate synthetase 2(OAS2) Homo sapiens This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates (2-5As). These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. The three known members of this gene family are located in a cluster on chromosome 12. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008], |
| Protein Expression | Blood,Colon,Testis,Uterus, |
| Subcellular Localization | nucleus,cytoplasm,mitochondrion,endoplasmic reticulum,cytosol,membrane,intracellular membrane-bounded organelle,perinuclear region of cytoplasm, |
| Protein Function | catalytic activity:Binds double-stranded RNA and polymerizes ATP into PPP(A2'P5'A)N oligomers, which activate the latent RNase L that, when activated, cleaves single-stranded RNAs.,function:May play a role in mediating resistance to virus infection, control of cell growth, differentiation, and apoptosis.,induction:By interferons.,similarity:Belongs to the 2-5A synthetase family.,subcellular location:Associated with different subcellular fractions such as mitochondrial, nuclear, and rough/smooth microsomal fractions.,subunit:Homodimer., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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