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ITT5575

ITT5575
ITT5575
  • Gene/Protein: SOD2
  • Product Description: Immunotag™ SOD-2 Polyclonal Antibody
  • 280.0000
    Price in reward points: 294

    Available Options

ITT5575

Immunotag™ SOD-2 Polyclonal Antibody
Antibody Specification
Datasheet
Target Protein SOD-2
Clonality Polyclonal
Storage/Stability -20°C/1 year
Application WB,IHC-p,ELISA
Recommended Dilution IHC-p: 100-300.Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
Concentration 1 mg/ml
Reactive Species Human,Mouse,Rat
Host Species Rabbit
Immunogen Synthesized peptide derived from SOD-2, at AA range: internal
Specificity SOD-2 Polyclonal Antibody detects endogenous levels of SOD-2 protein.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene Name SOD2
Accession No. P04179 P09671 P07895
Alternate Names SOD2; Superoxide dismutase [Mn], mitochondrial
Description superoxide dismutase 2, mitochondrial(SOD2) Homo sapiens This gene is a member of the iron/manganese superoxide dismutase family. It encodes a mitochondrial protein that forms a homotetramer and binds one manganese ion per subunit. This protein binds to the superoxide byproducts of oxidative phosphorylation and converts them to hydrogen peroxide and diatomic oxygen. Mutations in this gene have been associated with idiopathic cardiomyopathy (IDC), premature aging, sporadic motor neuron disease, and cancer. Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been identified on chromosome 1. [provided by RefSeq, Apr 2016],
Cell Pathway/ Category Huntington's disease,
Protein Expression Brain,Colon,Heart,Liver,Lung,Mammary carcinoma,Tongue,
Subcellular Localization mitochondrion,mitochondrial inner membrane,mitochondrial matrix,mitochondrial nucleoid,myelin sheath,extracellular exosome,
Protein Function catalytic activity:2 superoxide + 2 H(+) = O(2) + H(2)O(2).,cofactor:Binds 1 manganese ion per subunit.,disease:Genetic variation in SOD2 is associated with susceptibility to diabetic nephropathy [MIM:612634]; also called susceptibility to microvascular complications of diabetes type 6 (MVCD6). Diabetic nephropathy is a kidney disease and resultant kidney function impairment due to the long standing effects of diabetes on the microvasculature (glomerulus) of the kidney. Features include increased urine protein and declining kidney function.,function:Destroys radicals which are normally produced within the cells and which are toxic to biological systems.,online information:Superoxide dismutase entry,online information:The Singapore human mutation and polymorphism database,PTM:Nitrated under oxidative stress. Nitration coupled with oxidation inhibits the catalytic activity.,similarity:Belongs to the iron/manganese superoxide dismutase family.,subunit:Homotetramer.,
Usage For Research Use Only! Not for diagnostic or therapeutic procedures.
Material Safety Data Sheet
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