ITT5577
ITT5577
- Catalog: ITT5577
- Gene/Protein: CD6
- Product Description: Immunotag™ CD6 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | CD6 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,IHC-p,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. IHC-p: 1:100-1:300. ELISA: 1/10000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human |
| Host Species | Rabbit |
| Immunogen | The antiserum was produced against synthesized peptide derived from the Internal region of human CD6. AA range:361-410 |
| Specificity | CD6 Polyclonal Antibody detects endogenous levels of CD6 protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | CD6 |
| Accession No. | P30203 Q61003 |
| Alternate Names | CD6; T-cell differentiation antigen CD6; T12; TP120; CD6 |
| Description | CD6 molecule(CD6) Homo sapiens This gene encodes a protein found on the outer membrane of T-lymphocytes as well as some other immune cells. The encoded protein contains three scavenger receptor cysteine-rich (SRCR) domains and a binding site for an activated leukocyte cell adhesion molecule. The gene product is important for continuation of T cell activation. This gene may be associated with susceptibility to multiple sclerosis (PMID: 19525953, 21849685). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011], |
| Cell Pathway/ Category | Cell adhesion molecules (CAMs), |
| Protein Expression | Blood,Placenta,Spleen, |
| Subcellular Localization | immunological synapse,extracellular region,integral component of plasma membrane,membrane,integral component of membrane,intrinsic component of plasma membrane,T cell receptor complex, |
| Protein Function | function:Involved in cell adhesion. Binds to CD166.,PTM:After T-cell activation, becomes hyperphosphorylated on Ser and Thr residues and phosphorylated on Tyr residues.,PTM:Contains intrachain disulfide bond(s).,similarity:Contains 3 SRCR domains.,tissue specificity:Expressed by thymocytes, mature T-cells, a subset of B-cells known as B-1 cells, and by some cells in the brain., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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