ITT5603
ITT5603
- Catalog: ITT5603
- Gene/Protein: PVRL2
- Product Description: Immunotag™ Nectin 2 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
|
| Target Protein | Nectin 2 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from Poliovirus receptor-related protein 2 at AA range: 151-200 |
| Specificity | Nectin 2 Polyclonal Antibody detects endogenous levels of Nectin 2 protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | PVRL2 |
| Accession No. | Q92692 P32507 |
| Alternate Names | PVRL2; HVEB; PRR2; Poliovirus receptor-related protein 2; Herpes virus entry mediator B; Herpesvirus entry mediator B; HveB; Nectin-2; CD112 |
| Description | nectin cell adhesion molecule 2(NECTIN2) Homo sapiens This gene encodes a single-pass type I membrane glycoprotein with two Ig-like C2-type domains and an Ig-like V-type domain. This protein is one of the plasma membrane components of adherens junctions. It also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading of these viruses. Variations in this gene have been associated with differences in the severity of multiple sclerosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008], |
| Cell Pathway/ Category | Cell adhesion molecules (CAMs),Adherens_Junction, |
| Protein Expression | Brain,Epithelium, |
| Subcellular Localization | plasma membrane,integral component of plasma membrane,cell-cell junction,cell-cell adherens junction,zonula adherens,focal adhesion,cell surface,integral component of membrane,cell-cell contact zone,extracellular exosome, |
| Protein Function | function:Probable cell adhesion protein.,similarity:Belongs to the nectin family.,similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain.,similarity:Contains 2 Ig-like C2-type (immunoglobulin-like) domains.,subunit:Can form trans-heterodimers with PVRL3/nectin-3 (By similarity). Interacts with CD226. Receptor for alphaherpesvirus (HSV-1, HSV-2 and pseudorabies virus) entry into cells. Binds with low affinity to TIGIT.,tissue specificity:Ubiquitous., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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