ITT5647
ITT5647
- Catalog: ITT5647
- Gene/Protein: LEFTY1/LEFTY2
- Product Description: Immunotag™ Lefty Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | Lefty |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse |
| Host Species | Rabbit |
| Immunogen | The antiserum was produced against synthesized peptide derived from the C-terminal region of human LEFTY1/LEFTY2. AA range:301-350 |
| Specificity | Lefty Polyclonal Antibody detects endogenous levels of Lefty protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | LEFTY1/LEFTY2 |
| Accession No. | O75610/O00292 |
| Alternate Names | LEFTY1; LEFTB; LEFTYB; Left-right determination factor 1; Left-right determination factor B; Protein lefty-1; Protein lefty-B; LEFTY2; EBAF; LEFTA; LEFTYA; TGFB4; PSEC0024; Left-right determination factor 2; Endometrial bleeding-associated factor; Left-right determination factor A; Protein lefty-2; Protein lefty-A; Transforming growth factor beta-4; TGF-beta-4 |
| Description | left-right determination factor 1(LEFTY1) Homo sapiens This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate the mature protein, which plays a role in left-right asymmetry determination of organ systems during development. This gene is closely linked to both a related family member and a related pseudogene. [provided by RefSeq, Aug 2016], |
| Cell Pathway/ Category | TGF-beta, |
| Protein Expression | Colon,Pancreas,Spleen,Teratocarcinoma, |
| Subcellular Localization | extracellular space, |
| Protein Function | function:Required for left-right axis determination as a regulator of LEFTY2 and NODAL.,PTM:The processing of the protein may also occur at the second R-X-X-R site located at AA 132-135. Processing appears to be regulated in a cell-type specific manner.,similarity:Belongs to the TGF-beta family., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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