ITT5648
ITT5648
- Catalog: ITT5648
- Gene/Protein: NRG3
- Product Description: Immunotag™ Neuregulin-3 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | Neuregulin-3 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,IHC-p,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. IHC-p: 1:100-1:300. ELISA: 1/10000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse |
| Host Species | Rabbit |
| Immunogen | The antiserum was produced against synthesized peptide derived from the Internal region of human NRG3. AA range:311-360 |
| Specificity | Neuregulin-3 Polyclonal Antibody detects endogenous levels of Neuregulin-3 protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | NRG3 |
| Accession No. | P56975 O35181 |
| Alternate Names | NRG3; Pro-neuregulin-3, membrane-bound isoform; Pro-NRG3 |
| Description | neuregulin 3(NRG3) Homo sapiens This gene is a member of the neuregulin gene family. This gene family encodes ligands for the transmembrane tyrosine kinase receptors ERBB3 and ERBB4 - members of the epidermal growth factor receptor family. Ligand binding activates intracellular signaling cascades and the induction of cellular responses including proliferation, migration, differentiation, and survival or apoptosis. This gene encodes neuregulin 3 (NRG3). NRG3 has been shown to activate the tyrosine phosphorylation of its cognate receptor, ERBB4, and is thought to influence neuroblast proliferation, migration and differentiation by signalling through ERBB4. NRG3 also promotes mammary differentiation during embryogenesis. Linkage studies have implicated this gene as a susceptibility locus for schizophrenia and schizoaffective disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcri |
| Cell Pathway/ Category | ErbB_HER, |
| Protein Expression | Brain,Fetal brain,Testicle, |
| Subcellular Localization | extracellular region,extracellular space,intracellular,integral component of plasma membrane,integral component of membrane, |
| Protein Function | developmental stage:Isoform 3 is expressed in fetal brain but not in other fetal tissues.,domain:ERBB receptor binding is elicited entirely by the EGF-like domain.,domain:The cytoplasmic domain may be involved in the regulation of trafficking and proteolytic processing. Regulation of the proteolytic processing involves initial intracellular domain dimerization.,function:Direct ligand for the ERBB4 tyrosine kinase receptor. Binding results in ligand-stimulated tyrosine phosphorylation and activation of the receptor. Does not bind to the EGF receptor, ERBB2 or ERBB3 receptors. May be a survival factor for oligodendrocytes.,PTM:Extensive glycosylation precedes the proteolytic cleavage (By similarity). Isoform 3 is glycosylated.,PTM:Proteolytic cleavage close to the plasma membrane on the external face leads to the release of the soluble growth factor form.,similarity:Belongs to the neuregulin family.,similarity:Contains 1 EGF-like domain.,subcellular location:Does not seem to be active.,subcellular location:Isoform 3 is also proteolytically released as a soluble form.,tissue specificity:Highly expressed in most regions of the brain with the exception of corpus callosum. Expressed at lower level in testis. Not detected in heart, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, ovary, small intestine, colon and peripheral blood leukocytes., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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