ITT5651
ITT5651
- Catalog: ITT5651
- Gene/Protein: BMP2
- Product Description: Immunotag™ BMP-2 Polyclonal Antibody
385.0000
Price in reward points: 385
Your shopping cart is empty!
Antibody Specification | |
Datasheet | |
Target Protein | BMP-2 |
Clonality | Polyclonal |
Storage/Stability | -20°C/1 year |
Application | IF,WB,IHC-p,ELISA |
Recommended Dilution | IF: 1:50-200 Western Blot: 1/500 - 1/2000. IHC-p: 1:100-1:300. ELISA: 1/10000. Not yet tested in other applications. |
Concentration | 1 mg/ml |
Reactive Species | Human,Mouse,Rat |
Host Species | Rabbit |
Immunogen | Synthesized peptide derived from Bone morphogenetic protein 2 at AA range: 341-390 |
Specificity | BMP-2 Polyclonal Antibody detects endogenous levels of BMP-2 protein. |
Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Gene Name | BMP2 |
Accession No. | P12643 P21274 P49001 |
Alternate Names | BMP2; BMP2A; Bone morphogenetic protein 2; BMP-2; Bone morphogenetic protein 2A; BMP-2A |
Description | bone morphogenetic protein 2(BMP2) Homo sapiens This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which plays a role in bone and cartilage development. Duplication of a regulatory region downstream of this gene causes a form of brachydactyly characterized by a malformed index finger and second toe in human patients. [provided by RefSeq, Jul 2016], |
Cell Pathway/ Category | Cytokine-cytokine receptor interaction,Hedgehog,TGF-beta,Pathways in cancer,Basal cell carcinoma, |
Subcellular Localization | extracellular region,extracellular space,cell surface,BMP receptor complex, |
Protein Function | function:Induces cartilage and bone formation.,online information:Bone morphogenetic protein 2 entry,similarity:Belongs to the TGF-beta family.,subunit:Homodimer; disulfide-linked. Interacts with GREM2 (By similarity) and SOSTDC1.,tissue specificity:Particularly abundant in lung, spleen and colon and in low but significant levels in heart, brain, placenta, liver, skeletal muscle, kidney, pancreas, prostate, ovary and small intestine., |
Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |