ITT5676
ITT5676
- Catalog: ITT5676
- Gene/Protein: SLC9A3R2
- Product Description: Immunotag™ NHERF-2 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | NHERF-2 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from NHERF-2, at AA range: 20-100 |
| Specificity | NHERF-2 Polyclonal Antibody detects endogenous levels of NHERF-2 protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | SLC9A3R2 |
| Accession No. | Q15599 Q9JHL1 Q920G2 |
| Alternate Names | SLC9A3R2; NHERF2; Na(+)/H(+) exchange regulatory cofactor NHE-RF2; NHERF-2; NHE3 kinase A regulatory protein E3KARP; SRY-interacting protein 1; SIP-1; Sodium-hydrogen exchanger regulatory factor 2; Solute carrier family 9 isoform A3 regulatory factor 2; Tyrosine kinase activator protein 1; TKA-1 |
| Description | SLC9A3 regulator 2(SLC9A3R2) Homo sapiens This gene encodes a member of the NHERF family of PDZ scaffolding proteins. These proteins mediate many cellular processes by binding to and regulating the membrane expression and protein-protein interactions of membrane receptors and transport proteins. The encoded protein plays a role in intestinal sodium absorption by regulating the activity of the sodium/hydrogen exchanger 3, and may also regulate the cystic fibrosis transmembrane regulator (CFTR) ion channel. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011], |
| Cell Pathway/ Category | Aldosterone-regulated sodium reabsorption, |
| Protein Expression | Brain,Cervix carcinoma,Embryo,Epithelium,Fetal brain,Kidney,Lung,Placenta,Testis, |
| Subcellular Localization | nucleus,plasma membrane,cell-cell adherens junction,focal adhesion,endomembrane system,apical plasma membrane,extracellular exosome, |
| Protein Function | function:Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. May also act as scaffold protein in the nucleus.,similarity:Contains 2 PDZ (DHR) domains.,subcellular location:Nuclear, in a punctate pattern.,subunit:Homodimer, and heterodimer with SLC9A3R1. Binds PODXL and PDZK1 (By similarity). Binds ADRB2, SLC9A3, P2RY1, P2YR2, SRY, RDX and LPAR2.,tissue specificity:Widely expressed., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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