ITT5705
ITT5705
- Catalog: ITT5705
- Gene/Protein: MAOA
- Product Description: Immunotag™ MAO-A Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | MAO-A |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from MAO-A, at AA range: internal |
| Specificity | MAO-A Polyclonal Antibody detects endogenous levels of MAO-A protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | MAOA |
| Accession No. | P21397 Q64133 P21396 |
| Alternate Names | MAOA; Amine oxidase [flavin-containing] A; Monoamine oxidase type A; MAO-A |
| Description | monoamine oxidase A(MAOA) Homo sapiens This gene is one of two neighboring gene family members that encode mitochondrial enzymes which catalyze the oxidative deamination of amines, such as dopamine, norepinephrine, and serotonin. Mutation of this gene results in Brunner syndrome. This gene has also been associated with a variety of other psychiatric disorders, including antisocial behavior. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Jul 2012], |
| Cell Pathway/ Category | Glycine, serine and threonine metabolism,Arginine and proline metabolism,Histidine metabolism,Tyrosine metabolism,Phenylalanine metabolism,Tryptophan metabolism,Drug metabolism, |
| Protein Expression | Adipose tissue,Liver,Ovary,Placenta,Testis, |
| Subcellular Localization | mitochondrion,mitochondrial outer membrane,integral component of membrane, |
| Protein Function | catalytic activity:RCH(2)NHR' + H(2)O + O(2) = RCHO + R'NH(2) + H(2)O(2).,cofactor:FAD.,disease:Defects in MAOA are the cause of Brunner syndrome (BRUNS) [MIM:300615]. Brunner syndrome is a form of X-linked non-dysmorphic mild mental retardation. Male patients are affected by a syndrome of borderline mental retardation and exhibit abnormal behavior, including disturbed regulation of impulsive aggression. Obligate female carriers have normal intelligence and behavior.,function:Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine.,mass spectrometry: PubMed:11812236,online information:Monoamine oxidase entry,similarity:Belongs to the flavin monoamine oxidase family.,subunit:Monomer, homo- or heterodimer (containing two subunits of similar size). Each subunit contains a covalently bound flavin. Enzymatically active as monomer.,tissue specificity:Heart, liver, duodenum, blood vessels and kidney., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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