ITT5727
ITT5727
- Catalog: ITT5727
- Gene/Protein: NODAL
- Product Description: Immunotag™ Nodal Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | Nodal |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,IHC-p,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. IHC-p: 1:100-1:300. ELISA: 1/10000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Immunogen | The antiserum was produced against synthesized peptide derived from the C-terminal region of human NODAL. AA range:294-343 |
| Specificity | Nodal Polyclonal Antibody detects endogenous levels of Nodal protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | NODAL |
| Accession No. | Q96S42 P43021 |
| Alternate Names | NODAL; Nodal homolog |
| Description | nodal growth differentiation factor(NODAL) Homo sapiens This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate the mature protein, which regulates early embryonic development. This protein is required for maintenance of human embryonic stem cell pluripotency and may play a role in human placental development. Mutations in this gene are associated with heterotaxy, a condition characterized by random orientation of visceral organs with respect to the left-right axis. [provided by RefSeq, Aug 2016], |
| Cell Pathway/ Category | TGF-beta, |
| Protein Expression | Brain cortex,Fetal brain, |
| Subcellular Localization | extracellular region,extracellular space, |
| Protein Function | disease:Defects in NODAL may be a cause of situs ambiguus [MIM:601265].,function:Essential for mesoderm formation and axial patterning during embryonic development.,similarity:Belongs to the TGF-beta family.,subunit:Homodimer; disulfide-linked., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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