ITT5748
ITT5748
- Catalog: ITT5748
- Gene/Protein: KEL
- Product Description: Immunotag™ CD238 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
|
| Target Protein | CD238 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | WB 1:500-2000, ELISA 1:10000-20000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human |
| Host Species | Rabbit |
| Immunogen | The antiserum was produced against synthesized peptide derived from the Internal region of human KEL. AA range:351-400 |
| Specificity | CD238 Polyclonal Antibody detects endogenous levels of CD238 |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | KEL |
| Accession No. | P23276 Q9EQF2 |
| Alternate Names | Kell blood group, metallo-endopeptidase |
| Description | Kell blood group, metallo-endopeptidase(KEL) Homo sapiens This gene encodes a type II transmembrane glycoprotein that is the highly polymorphic Kell blood group antigen. The Kell glycoprotein links via a single disulfide bond to the XK membrane protein that carries the Kx antigen. The encoded protein contains sequence and structural similarity to members of the neprilysin (M13) family of zinc endopeptidases. [provided by RefSeq, Jul 2008], |
| Protein Expression | Blood,Brain,Peripheral blood,Skin, |
| Subcellular Localization | cell,plasma membrane,integral component of membrane, |
| Protein Function | cofactor:Binds 1 zinc ion per subunit.,function:Zinc endopeptidase with endothelin-3-converting enzyme activity.,online information:Blood group antigen gene mutation database,polymorphism:KEL is responsible for the Kell blood group system. The molecular basis of the K=KEL1/k=KEL2 blood group antigens is a single variation in position 193; Thr-193 corresponds to KEL2 and Met-193 to KEL1. The molecular basis of the Kpa=KEL3/Kpb=KEL4/Kpc=KEL21 blood group antigens is a single variation in position 281; Arg-281 corresponds to KEL4, Trp-281 to KEL3 and Gln-281 to KEL21. The molecular basis of the Jsa=KEL6/Jsb=KEL7 blood group antigens is a single variation in position 597; Leu-597 corresponds to KEL7 and Pro-597 to KEL6. The molecular basis of the KEL11/KEL17 blood group antigens is a single variation in position 302; Val-302 corresponds to KEL11 and Ala-302 to KEL17. The molecular basis of the KEL14/KEL24 blood group antigens is a single variation in position 180; Arg-180 corresponds to KEL14 and Pro-180 to KEL24.,similarity:Belongs to the peptidase M13 family.,subcellular location:Spans the erythrocyte membrane, and is attached to the underlying cytoskeleton.,subunit:Heterodimer with XK; disulfide-linked., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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