ITT5827
ITT5827
- Catalog: ITT5827
- Gene/Protein: MYOZ2 C4orf5
- Product Description: Immunotag™ MYOZ2 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | MyoZ2 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | WB 1:500-2000, ELISA 1:10000-20000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Immunogen | The antiserum was produced against synthesized peptide derived from the Internal region of human MYOZ2. AA range:21-70 |
| Specificity | The antibody detects endogenous MYOZ2 protein |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | MYOZ2 C4orf5 |
| Accession No. | Q9NPC6 Q9JJW5 |
| Alternate Names | MYOZ2 C4orf5 |
| Description | myozenin 2(MYOZ2) Homo sapiens The protein encoded by this gene belongs to a family of sarcomeric proteins that bind to calcineurin, a phosphatase involved in calcium-dependent signal transduction in diverse cell types. These family members tether calcineurin to alpha-actinin at the z-line of the sarcomere of cardiac and skeletal muscle cells, and thus they are important for calcineurin signaling. Mutations in this gene cause cardiomyopathy familial hypertrophic type 16, a hereditary heart disorder. [provided by RefSeq, Aug 2011], |
| Protein Expression | Brain,Heart,Liver,Skeletal muscle, |
| Subcellular Localization | actin cytoskeleton,sarcomere,Z disc, |
| Protein Function | function:Myozenins may serve as intracellular binding proteins involved in linking Z-disk proteins such as alpha-actinin, gamma-filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis.,similarity:Belongs to the myozenin family.,subcellular location:Colocalizes with ACTN1 and PPP3CA at the Z-line of heart and skeletal muscle.,subunit:Interacts via its C-terminus with spectrin repeats 3 and 4 of ACTN2. Interacts with ATCN1, LDB3, MYOT and PPP3CA.,tissue specificity:Expressed specifically in heart and skeletal muscle., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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