ITT5829
ITT5829
- Catalog: ITT5829
- Gene/Protein: PENK
- Product Description: Immunotag™ PENK Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | PENK |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | WB 1:500-2000, ELISA 1:10000-20000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human |
| Host Species | Rabbit |
| Immunogen | Synthetic peptide from human protein at AA range: 51-100 |
| Specificity | The antibody detects endogenous PENK protein |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | PENK |
| Accession No. | P01210 P22005 |
| Alternate Names | PENK |
| Description | proenkephalin(PENK) Homo sapiens This gene encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include the pentapeptide opioids Met-enkephalin and Leu-enkephalin, which are stored in synaptic vesicles, then released into the synapse where they bind to mu- and delta-opioid receptors to modulate the perception of pain. Other non-opioid cleavage products may function in distinct biological activities. [provided by RefSeq, Jul 2015], |
| Protein Expression | Brain,Cerebellum,Testis, |
| Subcellular Localization | extracellular region,plasma membrane,dendrite,symmetric synapse,neuronal cell body,perikaryon,axon terminus,cell body fiber, |
| Protein Function | function:Met- and Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress. PENK(114-133) and PENK(237-258) increase glutamate release in the striatum. PENK(114-133) decreases GABA concentration in the striatum.,PTM:The N-terminal domain contains 6 conserved cysteines thought to be involved in disulfide bonding and/or processing.,similarity:Belongs to the opioid neuropeptide precursor family., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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