ITT5880
ITT5880
- Catalog: ITT5880
- Gene/Protein: EGF
- Product Description: Immunotag™ EGF Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | EGF |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,IHC-p,ELISA |
| Recommended Dilution | WB 1:500-2000,IHC-p 1:500-200, ELISA 1:10000-20000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human |
| Host Species | Rabbit |
| Immunogen | Synthetic peptide from human protein at AA range: 1000-1060 |
| Specificity | The antibody detects endogenous EGF |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | EGF |
| Accession No. | P01133 P01132 |
| Alternate Names | Pro-epidermal growth factor (EGF) [Cleaved into: Epidermal growth factor (Urogastrone)] |
| Description | epidermal growth factor(EGF) Homo sapiens This gene encodes a member of the epidermal growth factor superfamily. The encoded preproprotein is proteolytically processed to generate the 53-amino acid epidermal growth factor peptide. This protein acts a potent mitogenic factor that plays an important role in the growth, proliferation and differentiation of numerous cell types. This protein acts by binding with high affinity to the cell surface receptor, epidermal growth factor receptor. Defects in this gene are the cause of hypomagnesemia type 4. Dysregulation of this gene has been associated with the growth and progression of certain cancers. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. [provided by RefSeq, Jan 2016], |
| Cell Pathway/ Category | MAPK_ERK_Growth,MAPK_G_Protein,ErbB_HER,Cytokine-cytokine receptor interaction,Endocytosis,Focal adhesion,Gap junction,Regulates Actin and Cytoskeleton,Pathways in cancer,Pancreatic cancer,Endometrial cancer,Glioma,Prostate cancer,Melanoma,Bladder cancer,Non-small cell lung cancer, |
| Protein Expression | Colon,Kidney, |
| Subcellular Localization | extracellular region,extracellular space,lysosomal membrane,plasma membrane,integral component of membrane,platelet alpha granule lumen,receptor complex,extracellular exosome, |
| Protein Function | disease:Defects in EGF are the cause of hypomagnesemia type 4 (HOMG4) [MIM:611718]; also known as renal hypomagnesemia normocalciuric. HOMG4 is a disorder characterized by massive renal hypomagnesemia and normal levels of serum calcium and calcium excretion. Clinical features include seizures, mild-to mederate psychomotor retardation, and brisk tendon reflexes.,function:EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.,online information:Epidermal growth factor entry,similarity:Contains 9 EGF-like domains.,similarity:Contains 9 LDL-receptor class B repeats.,tissue specificity:Expressed in kidney, salivary gland, cerebrum and prostate., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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