ITT5912
ITT5912
- Catalog: ITT5912
- Gene/Protein: ANG RNASE5
- Product Description: Immunotag™ ANG I Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | ANG I |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | IHC-p,ELISA |
| Recommended Dilution | IHC-p 1:50-200, ELISA 1:10000-20000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human |
| Host Species | Rabbit |
| Immunogen | Synthetic peptide from human protein at AA range: 20-60 |
| Specificity | The antibody detects endogenous ANG I |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | ANG RNASE5 |
| Accession No. | P03950 P21570 |
| Alternate Names | Angiogenin (EC 3.1.27.-) (Ribonuclease 5) (RNase 5) |
| Description | angiogenin(ANG) Homo sapiens The protein encoded by this gene is an exceedingly potent mediator of new blood vessel formation. It hydrolyzes cellular tRNAs resulting in decreased protein synthesis and is similar to pancreatic ribonuclease. In addition, the mature peptide has antimicrobial activity against some bacteria and fungi, including S. pneumoniae and C. albicans. Alternative splicing results in two transcript variants encoding the same protein. This gene and the gene that encodes ribonuclease, RNase A family, 4 share promoters and 5' exons. Each gene splices to a unique downstream exon that contains its complete coding region. [provided by RefSeq, Aug 2014], |
| Protein Expression | Liver,Small intestine, |
| Subcellular Localization | extracellular region,basal lamina,extracellular space,nucleus,nucleolus,cytoplasmic, membrane-bounded vesicle,growth cone,cytoplasmic vesicle,angiogenin-PRI complex,neuronal cell body,extracellular exosome, |
| Protein Function | caution:It is uncertain whether Met-1 or Met-3 is the initiator.,developmental stage:Low level expression in the developing fetus, increased in the neonate, and maximal in the adult.,disease:Defects in ANG are the cause of susceptibility to amyotrophic lateral sclerosis type 9 (ALS9) [MIM:611895]. ALS is a degenerative disorder of motor neurons in the cortex, brain stem and spinal cord. ALS is characterized by muscular weakness and atrophy.,function:May function as a tRNA-specific ribonuclease that binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus, thereby promoting the endothelial invasiveness necessary for blood vessel formation. Angiogenin induces vascularization of normal and malignant tissues. Abolishes protein synthesis by specifically hydrolyzing cellular tRNAs.,online information:Angiogenin,similarity:Belongs to the pancreatic ribonuclease family.,tissue specificity:Expressed predominantly in the liver. Also detected in endothelial cells and spinal cord neurons., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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