ITT5917
ITT5917
- Catalog: ITT5917
- Gene/Protein: VCAN CSPG2
- Product Description: Immunotag™ Versican Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | Versican |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | IHC-p,ELISA |
| Recommended Dilution | IHC-p 1:50-200, ELISA 1:10000-20000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Immunogen | Synthetic peptide from human protein at AA range: 2530-2580 |
| Specificity | The antibody detects endogenous Versican |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | VCAN CSPG2 |
| Accession No. | P13611 Q62059 Q9ERB4 |
| Alternate Names | Versican core protein (Chondroitin sulfate proteoglycan core protein 2) (Chondroitin sulfate proteoglycan 2) (Glial hyaluronate-binding protein) (GHAP) (Large fibroblast proteoglycan) (PG-M) |
| Description | versican(VCAN) Homo sapiens This gene is a member of the aggrecan/versican proteoglycan family. The protein encoded is a large chondroitin sulfate proteoglycan and is a major component of the extracellular matrix. This protein is involved in cell adhesion, proliferation, proliferation, migration and angiogenesis and plays a central role in tissue morphogenesis and maintenance. Mutations in this gene are the cause of Wagner syndrome type 1. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009], |
| Cell Pathway/ Category | Cell adhesion molecules (CAMs), |
| Protein Expression | Aortic smooth muscle,Blood,Brain,Glial tumor,Human fetal kidney,Lung fibroblast,Placenta, |
| Subcellular Localization | extracellular region,proteinaceous extracellular matrix,extracellular space,Golgi lumen,membrane,extracellular matrix,lysosomal lumen,intracellular membrane-bounded organelle, |
| Protein Function | Additional isoforms seem to exist,developmental stage:Disappears after the cartilage development.,disease:Defects in VCAN are the cause of Wagner syndrome type 1 (WGN1) [MIM:143200]. WGN is a dominantly inherited vitreoretinopathy characterized by an optically empty vitreous cavity with fibrillary condensations and a preretinal avascular membrane. Other optical features include progressive chorioretinal atrophy, perivascular sheating, subcapsular cataract and myopia. Systemic manifestations are absent in WGN.,function:May play a role in intercellular signaling and in connecting cells with the extracellular matrix. May take part in the regulation of cell motility, growth and differentiation. Binds hyaluronic acid.,online information:Versican,similarity:Belongs to the aggrecan/versican proteoglycan family.,similarity:Contains 1 C-type lectin domain.,similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain.,similarity:Contains 1 Sushi (CCP/SCR) domain.,similarity:Contains 2 EGF-like domains.,similarity:Contains 2 Link domains.,subunit:Interacts with FBLN1.,tissue specificity:Cerebral white matter. Isoform V0 and isoform V1 are expressed in normal brain, gliomas, medulloblastomas, schwannomas, neurofibromas, and meningiomas; isoform V2 is restricted to normal brain and gliomas; isoform V3 is found in all these tissues except medulloblastomas., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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