ITT5964
ITT5964
- Catalog: ITT5964
- Gene/Protein: IFNB1 IFB IFNB
- Product Description: Immunotag™ IFN-β Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | IFN-β |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | IHC-p,ELISA |
| Recommended Dilution | IHC-p 1:50-200, ELISA 1:10000-20000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human |
| Host Species | Rabbit |
| Immunogen | Synthetic peptide from human protein at AA range: 91-140 |
| Specificity | The antibody detects endogenous IFN-β |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | IFNB1 IFB IFNB |
| Accession No. | P01574 P01575 |
| Alternate Names | Interferon beta (IFN-beta) (Fibroblast interferon) |
| Description | interferon beta 1(IFNB1) Homo sapiens This gene encodes a cytokine that belongs to the interferon family of signaling proteins, which are released as part of the innate immune response to pathogens. The protein encoded by this gene belongs to the type I class of interferons, which are important for defense against viral infections. In addition, type I interferons are involved in cell differentiation and anti-tumor defenses. Following secretion in response to a pathogen, type I interferons bind a homologous receptor complex and induce transcription of genes such as those encoding inflammatory cytokines and chemokines. Overactivation of type I interferon secretion is linked to autoimmune diseases. Mice deficient for this gene display several phenotypes including defects in B cell maturation and increased susceptibility to viral infection. [provided by RefSeq, Sep 2015], |
| Cell Pathway/ Category | Cytokine-cytokine receptor interaction,Toll_Like,RIG-I-like receptor,Cytosolic DNA-sensing pathway,Jak_STAT,Natural killer cell mediated cytotoxicity, |
| Protein Expression | PCR rescued clones, |
| Subcellular Localization | extracellular region,extracellular space, |
| Protein Function | function:Has antiviral, antibacterial and anticancer activities.,online information:Clinical information on Avonex,online information:Clinical information on Betaseron,pharmaceutical:Available under the names Avonex (Biogen), Betaseron (Berlex) and Rebif (Serono). Used in the treatment of multiple sclerosis (MS). Betaseron is a slightly modified form of IFNB1 with two residue substitutions.,similarity:Belongs to the alpha/beta interferon family.,subunit:Monomer., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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