ITT5983
ITT5983
- Catalog: ITT5983
- Gene/Protein: PON1 PON
- Product Description: Immunotag™ PON1 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | PON1 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | IHC-p,ELISA |
| Recommended Dilution | IHC-p 1:50-200, ELISA 1:10000-20000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human |
| Host Species | Rabbit |
| Immunogen | The antiserum was produced against synthesized peptide derived from the Internal region of human PON1. AA range:51-100 |
| Specificity | The antibody detects endogenous PON1 |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | PON1 PON |
| Accession No. | P27169 P52430 |
| Alternate Names | Serum paraoxonase/arylesterase 1 (PON 1) (EC 3.1.1.2) (EC 3.1.1.81) (EC 3.1.8.1) (Aromatic esterase 1) (A-esterase 1) (K-45) (Serum aryldialkylphosphatase 1) |
| Description | paraoxonase 1(PON1) Homo sapiens The enzyme encoded by this gene is an arylesterase that mainly hydrolyzes paroxon to produce p-nitrophenol. Paroxon is an organophosphorus anticholinesterase compound that is produced in vivo by oxidation of the insecticide parathion. Polymorphisms in this gene are a risk factor in coronary artery disease. The gene is found in a cluster of three related paraoxonase genes at 7q21.3. [provided by RefSeq, Oct 2008], |
| Protein Expression | Brain,Liver,Lymphoblast,Plasma, |
| Subcellular Localization | extracellular region,extracellular space,high-density lipoprotein particle,spherical high-density lipoprotein particle,intracellular membrane-bounded organelle,extracellular exosome,blood microparticle, |
| Protein Function | catalytic activity:A phenyl acetate + H(2)O = a phenol + acetate.,catalytic activity:An aryl dialkyl phosphate + H(2)O = dialkyl phosphate + an aryl alcohol.,disease:Genetic variation in PON1 is associated with susceptibility to diabetic retinopathy [MIM:612633]; also called microvascular complications of diabetes type 5 (MVCD5). Diabetic retinopathy is a major cause of blindness in diabetic patients. Retinal disease results from adverse effects on the blood vessels which supply the retina.,function:Hydrolyzes the toxic metabolites of a variety of organophosphorus insecticides. Capable of hydrolyzing a broad spectrum of organophosphate substrates and a number of aromatic carboxylic acid esters. May mediate an enzymatic protection of low density lipoproteins against oxidative modification and the consequent series of events leading to atheroma formation.,miscellaneous:The preferential association of PON1 with HDL is mediated in part by its signal peptide, by binding phospholipids directly, rather than binding apo AI. The retained signal peptide may allow transfer of the protein between phospholipid surfaces.,online information:The Singapore human mutation and polymorphism database,polymorphism:The allelic form of the enzyme with Gln-192 (allozyme A) hydrolyzes paraoxon with a low turnover number and the one with Arg-192 (allozyme B) with a high turnover number.,PTM:Glycosylated.,PTM:Present in two forms, form B contains a disulfide bond, form A does not.,PTM:The signal sequence is not cleaved.,similarity:Belongs to the paraoxonase family.,subunit:Heterooligomer with phosphate-binding protein (HPBP). Interacts with CLU.,tissue specificity:Plasma, associated with HDL (at protein level). Expressed in liver, but not in heart, brain, placenta, lung, skeletal muscle, kidney or pancreas., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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