ITT6010
ITT6010
- Catalog: ITT6010
- Gene/Protein: PPP1R13B ASPP1 KIAA0771
- Product Description: Immunotag™ ASPP1 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | ASPP1 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | IHC-p,ELISA |
| Recommended Dilution | IHC-p 1:50-200, ELISA 1:10000-20000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human |
| Host Species | Rabbit |
| Immunogen | Synthetic peptide from human protein at AA range: 630-680 |
| Specificity | The antibody detects endogenous ASPP1 |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | PPP1R13B ASPP1 KIAA0771 |
| Accession No. | Q96KQ4 Q62415 |
| Alternate Names | Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B) |
| Description | protein phosphatase 1 regulatory subunit 13B(PPP1R13B) Homo sapiens This gene encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. The protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. ASPP proteins are required for the induction of apoptosis by p53-family proteins. They promote DNA binding and transactivation of p53-family proteins on the promoters of proapoptotic genes. Expression of this gene is regulated by the E2F transcription factor. [provided by RefSeq, Jul 2008], |
| Protein Expression | Brain,Pooled,Testis, |
| Subcellular Localization | nucleus,nucleoplasm,cytoplasm,mitochondrion,plasma membrane,perinuclear region of cytoplasm, |
| Protein Function | disease:Defects in PPP1R13B may be a cause of breast cancers. It is overexpressed in many patients suffering from breast carcinomas and expressing a wild-type TP53 protein.,domain:The ankyrin repeats and the SH3 domain are required for specific interactions with TP53.,function:Regulator that plays a central role in regulation of apoptosis via its interaction with p53/TP53. Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo.,miscellaneous:In contrast to its official gene name, it is not a regulatory subunit of protein phosphatase 1. This name was given due to its similarity with a protein that binds to protein phosphatase 1.,similarity:Belongs to the ASPP family.,similarity:Contains 1 SH3 domain.,similarity:Contains 2 ANK repeats.,subcellular location:Predominantly cytoplasmic. Some fraction is nuclear.,subunit:Interacts with TP53., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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