ITT6017
ITT6017
- Catalog: ITT6017
- Gene/Protein: INS
- Product Description: Immunotag™ Insulin Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | Insulin |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | IHC-p,ELISA |
| Recommended Dilution | IHC-p 1:50-200, ELISA 1:10000-20000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Immunogen | Synthetic peptide from human protein at AA range: 30-70 |
| Specificity | The antibody detects endogenous Insulin |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | INS |
| Accession No. | P01308 |
| Alternate Names | Insulin [Cleaved into: Insulin B chain; Insulin A chain] |
| Description | insulin(INS) Homo sapiens After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010], |
| Cell Pathway/ Category | Oocyte meiosis,Regulation of autophagy,mTOR,Regulates Actin and Cytoskeleton,Insulin_Receptor,Progesterone-mediated oocyte maturation,Type II diabetes mellitus,Type I diabetes mellitus,Maturity onset diabetes of the young,Aldosterone-regulated sodium reabsorption,Prostate cancer, |
| Protein Expression | Blood,Liver,Muscle,Pancreas, |
| Subcellular Localization | Golgi membrane,extracellular region,extracellular space,endoplasmic reticulum lumen,Golgi lumen,transport vesicle,endosome lumen,endoplasmic reticulum-Golgi intermediate compartment membrane,secretory granule lumen, |
| Protein Function | disease:Defects in INS are the cause of familial hyperproinsulinemia [MIM:176730].,function:Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.,function:Preptin undergoes glucose-mediated co-secretion with insulin, and acts as physiological amplifier of glucose-mediated insulin secretion. Exhibits osteogenic properties by increasing osteoblast mitogenic activity through phosphoactivation of MAPK1 and MAPK3.,function:The insulin-like growth factors possess growth-promoting activity. In vitro, they are potent mitogens for cultured cells. IGF-II is influenced by placental lactogen and may play a role in fetal development.,mass spectrometry: PubMed:12586351; PubMed:15359740,online information:Clinical information on Eli Lilly insulin products,online information:Insulin entry,online information:Insulin-like growth factor 2 entry,online information:Protein of the 20th century - Issue 9 of April 2001,pharmaceutical:Available under the names Humulin or Humalog (Eli Lilly) and Novolin (Novo Nordisk). Used in the treatment of diabetes. Humalog is an insulin analog with 52-Lys-Pro-53 instead of 52-Pro-Lys-53.,similarity:Belongs to the insulin family.,subunit:Heterodimer of a B chain and an A chain linked by two disulfide bonds., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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