ITT6026
ITT6026
- Catalog: ITT6026
- Gene/Protein: CD1A CD1B
- Product Description: Immunotag™ CD1A/B Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | CD1A/B |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | IHC-p,ELISA |
| Recommended Dilution | IHC-p 1:50-200, ELISA 1:10000-20000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human |
| Host Species | Rabbit |
| Immunogen | Synthetic peptide from human protein at AA range: 220-270 |
| Specificity | The antibody detects endogenous CD1A/B |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | CD1A CD1B |
| Accession No. | P06126/P29016 |
| Description | CD1a molecule(CD1A) Homo sapiens This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes to the plasma membrane and to recycling vesicles of the early endocytic system. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016], |
| Cell Pathway/ Category | Hematopoietic cell lineage, |
| Protein Expression | Brain,T-cell, |
| Subcellular Localization | plasma membrane,integral component of plasma membrane,endosome membrane,integral component of membrane,membrane raft, |
| Protein Function | function:Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells.,miscellaneous:During protein synthesis and maturation, CD1 family members bind endogenous lipids that are replaced by lipid or glycolipid antigens when the proteins are internalized and pass through endosomes, before trafficking back to the cell surface.,similarity:Contains 1 Ig-like (immunoglobulin-like) domain.,subcellular location:Subject to intracellular trafficking between the cell membrane and endosomes. Localizes to cell surface lipid rafts.,subunit:Heterodimer with B2M (beta-2-microglobulin). Interacts with CD74.,tissue specificity:Expressed on cortical thymocytes, epidermal Langerhans cells, dendritic cells, on certain T-cell leukemias, and in various other tissues., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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