ITT6052
ITT6052
- Catalog: ITT6052
- Gene/Protein: NAIP BIRC1
- Product Description: Immunotag™ NAIP Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
|
| Target Protein | NAIP |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | IHC-p,ELISA |
| Recommended Dilution | IHC-p 1:50-200, ELISA 1:10000-20000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse |
| Host Species | Rabbit |
| Immunogen | Synthetic peptide from human protein at AA range: 1191-1240 |
| Specificity | The antibody detects endogenous NAIP |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | NAIP BIRC1 |
| Accession No. | Q13075 |
| Alternate Names | Baculoviral IAP repeat-containing protein 1 (Neuronal apoptosis inhibitory protein) |
| Description | NLR family apoptosis inhibitory protein(NAIP) Homo sapiens This gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. This copy of the gene is full length; additional copies with truncations and internal deletions are also present in this region of chromosome 5q13. It is thought that this gene is a modifier of spinal muscular atrophy caused by mutations in a neighboring gene, SMN1. The protein encoded by this gene contains regions of homology to two baculovirus inhibitor of apoptosis proteins, and it is able to suppress apoptosis induced by various signals. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by Ref |
| Cell Pathway/ Category | NOD-like receptor, |
| Protein Expression | Brain,Fetal brain,Liver,Pre-B cell, |
| Subcellular Localization | cytoplasm,basolateral plasma membrane,neuron projection,perikaryon,extracellular exosome, |
| Protein Function | disease:Mutated or deleted forms of NAIP have been found in individuals with severe spinal muscular atrophy (SMA) leading to the hypothesis that mutations in the NAIP locus may contribute to the SMA phenotype.,function:Prevents motor-neuron apoptosis induced by a variety of signals.,similarity:Contains 1 NACHT domain.,similarity:Contains 3 BIR repeats.,tissue specificity:Expressed in motor neurons, but not in sensory neurons. Found in liver and placenta, and to a lesser extent in spinal cord., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
| English_US |
|
| Danish |
|
| Dutch |
|
| English_UK |
|
| French |
|
| German |
|
| Spanish |
|
| Norwegian |
|
| Portuguese |
|
| Finnish |
|
| Swedish |
|
| Polish |
|