ITT6106
ITT6106
- Catalog: ITT6106
- Gene/Protein: TH TYH
- Product Description: Immunotag™ Tyrosine Hydroxylase Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | Tyrosine Hydroxylase |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | WB 1:500-2000, ELISA 1:10000-20000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from human Tyrosine Hydroxylase Polyclonal |
| Specificity | This antibody detects endogenous levels of Tyrosine Hydroxylase. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | TH TYH |
| Accession No. | P07101 P24529 P04177 |
| Alternate Names | Tyrosine 3-monooxygenase (EC 1.14.16.2) (Tyrosine 3-hydroxylase) (TH) |
| Description | tyrosine hydroxylase(TH) Homo sapiens The protein encoded by this gene is involved in the conversion of tyrosine to dopamine. It is the rate-limiting enzyme in the synthesis of catecholamines, hence plays a key role in the physiology of adrenergic neurons. Mutations in this gene have been associated with autosomal recessive Segawa syndrome. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jul 2008], |
| Cell Pathway/ Category | Tyrosine metabolism,Parkinson's disease, |
| Protein Expression | Brain,Neuroblastoma,Pheochromocytoma,Placenta,Temporal cortex,Whole placenta, |
| Subcellular Localization | nucleus,cytoplasm,mitochondrion,smooth endoplasmic reticulum,cytosol,synaptic vesicle,cytoplasmic side of plasma membrane,dendrite,cytoplasmic vesicle,melanosome membrane,neuron projection,terminal bouton,perikaryon, |
| Protein Function | catalytic activity:L-tyrosine + tetrahydrobiopterin + O(2) = 3,4-dihydroxy-L-phenylalanine + 4a-hydroxytetrahydrobiopterin.,cofactor:Fe(2+) ion.,disease:Defects in TH are the cause of dystonia DOPA-responsive autosomal recessive (ARDRD) [MIM:605407]; also known as autosomal recessive Segawa syndrome. ARDRD is a form of DOPA-responsive dystonia presenting in infancy or early childhood. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures. Some cases of ARDRD present with parkinsonian symptoms in infancy. Unlike all other forms of dystonia, it is an eminently treatable condition, due to a favorable response to L-DOPA.,enzyme regulation:Phosphorylation leads to an increase in the catalytic activity.,function:Plays an important role in the physiology of adrenergic neurons.,online information:Tyrosine hydroxylase entry,pathway:Catecholamine biosynthesis; dopamine biosynthesis; dopamine from L-tyrosine: step 1/2.,similarity:Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.,tissue specificity:Mainly expressed in the brain and adrenal glands., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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