ITT6137
ITT6137
- Catalog: ITT6137
- Gene/Protein: GZMB CGL1 CSPB CTLA1 GRB
- Product Description: Immunotag™ Granzyme B Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | Granzyme B |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,IHC-p,ELISA |
| Recommended Dilution | IHC-p: 100-300.WB 1:500-2000, ELISA 1:10000-20000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from human Granzyme B Polyclonal |
| Specificity | This antibody detects endogenous levels of Granzyme B. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | GZMB CGL1 CSPB CTLA1 GRB |
| Accession No. | P10144 P04187 P18291 |
| Alternate Names | Granzyme B (EC 3.4.21.79) (C11) (CTLA-1) (Cathepsin G-like 1) (CTSGL1) (Cytotoxic T-lymphocyte proteinase 2) (Lymphocyte protease) (Fragmentin-2) (Granzyme-2) (Human lymphocyte protein) (HLP) (SECT) (T-cell serine protease 1-3E) |
| Description | granzyme B(GZMB) Homo sapiens This gene encodes a member of the granzyme subfamily of proteins, part of the peptidase S1 family of serine proteases. The encoded preproprotein is secreted by natural killer (NK) cells and cytotoxic T lymphocytes (CTLs) and proteolytically processed to generate the active protease, which induces target cell apoptosis. This protein also processes cytokines and degrades extracellular matrix proteins, and these roles are implicated in chronic inflammation and wound healing. Expression of this gene may be elevated in human patients with cardiac fibrosis. [provided by RefSeq, Sep 2016], |
| Cell Pathway/ Category | Natural killer cell mediated cytotoxicity,Type I diabetes mellitus,Autoimmune thyroid disease,Allograft rejection,Graft-versus-host disease, |
| Protein Expression | Breast carcinoma,Large granular lymphocyte leukemia,Pancreas, |
| Subcellular Localization | immunological synapse,nucleus,cytoplasm,mitochondrion,cytosol,membrane,intracellular membrane-bounded organelle, |
| Protein Function | catalytic activity:Preferential cleavage: -Asp-|-Xaa- >> -Asn-|-Xaa- > -Met-|-Xaa-, -Ser-|-Xaa-.,function:This enzyme is necessary for target cell lysis in cell-mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis.,induction:By staphylococcal enterotoxin A (SEA) in peripheral blood leukocytes.,similarity:Belongs to the peptidase S1 family.,similarity:Belongs to the peptidase S1 family. Granzyme subfamily.,similarity:Contains 1 peptidase S1 domain.,subcellular location:Cytoplasmic granules of cytolytic T-lymphocytes and natural killer cells., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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