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G-Biosciences Carboxylation Kit With Citraconic Anhydride is designed for reversible blocking of primary amines so that directed conjugation or labeling can be performed. Citraconic anhydride reacts with primary amines and blocks them by creating an amide linkage and a terminal carboxylate. The linkage is stable at neutral to alkaline pH (pH >7) and at acidic conditions (pH 4) the amide linkage is rapidly hydrolyzed to release the citraconic acid and free the amines. This property makes citraconic anhydride a very useful tool for blocking free amines in proteins and other biomolecules.
Features
Application(s)
reversible blocks primary amines so that directed conjugation or labeling of proteins can be done